Pegylated interferon for the treatment of high-risk essential thrombocythemia.
نویسنده
چکیده
Acute Myeloid Leukemia 1339-1345 Allogeneic stem cell transplantation for patients with acute myeloid leukemia or myelodysplastic syndrome having chromosome 5 and/or 7 abnormalities Hanneke M. van der Straaten, Anja van Biezen, Ronald Brand, Anton V.M.B. Schattenberg, Roel M. Egeler, Renée M. Barge, Jan J. Cornelissen, Harry C. Schouten, Gert J. Ossenkoppele, Leo F. Verdonck on behalf of the Netherlands Stem Cell Transplant Registry “TYPHON”
منابع مشابه
Pegylated interferon for the treatment of high risk essential thrombocythemia: results of a phase II study.
BACKGROUND AND OBJECTIVES Patients with high-risk essential thrombocythemia require cytoreductive therapy in order to normalize the elevated platelet counts. We evaluated the efficacy and toxicity of pegylated interferon in high-risk essential thrombocythemia in a phase II trial. DESIGN AND METHODS Thirty-six patients with high-risk essential thrombocythemia (median age 54 years; range, 24-72...
متن کاملExperience with pegylated interferon α-2a in advanced myeloproliferative neoplasms in an international cohort of 118 patients.
The Philadelphia negative myeloproliferative neoplasms, including polycythemia vera, essential thrombocythemia, and myelofibrosis, are associated with substantial vascular and transformative complications. Standard therapy for high-risk disease, particularly in patients that have failed initial therapy, remains controversial. Non-pegylated interferon has previously been shown to be effective in...
متن کاملManagement of thrombocythemia
Essential thrombocythemia is a clonal myeloproliferative neoplasm characterized by an elevated platelet count, the potential for both microvascular and macrovascular sequelae, and a risk for transformation to myelofibrosis or acute myeloid leukemia. A systematic and detailed initial analysis is essential for accurate diagnosis of essential thrombocythemia, as many etiologies are reactive and be...
متن کاملPegylated interferon alpha-2a for essential thrombocythemia during pregnancy: outcome and safety. A case series.
Pregnant woman with essential thrombocythemia (ET) are at higher than normal risk of pregnancy complications. Current recommendations suggest that aspirin and cytoreductive therapy should be offered for high-risk pregnancies but Pegylated interferon alpha-2a (PEG-IFN) has never been investigated in this context. From our case series, including 10 pregnancies, we demonstrate that PEG-IFN has bee...
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Background: Interferons (IFNs) are common therapeutics for several diseases such as viral hepatitis, multiple sclerosis and malignancy. A variety of autoimmune related side effects have been observed during IFN therapy. Rare cases of myopathy, polymyositis or dermatomyositis have been reported during therapy with high doses of IFN^5. Case Presentation: In this report, we describe a case with se...
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ورودعنوان ژورنال:
- Haematologica
دوره 90 10 شماره
صفحات -
تاریخ انتشار 2005